Cetaphil Advanced Defence Serum (AM) 30ml

Name: Cetaphil Advanced Defence Serum (AM) 30ml
Brand: Cetaphil
SKU: 3499320018067
Availability: InStock

Cetaphil Advanced Defence Serum (AM) 30ml

Protect your skin every morning with Cetaphil Advanced Defence (AM) Serum, clinically proven to strengthen sensitive skin against daily stressors.

Formulated with Gallic-AOX Power™, a potent antioxidant complex featuring Gallic Acid and Vitamin E, proven to be two times more effective than Vitamin C for sensitive skin. Combined with Triple Hyaluronic Acid and Niacinamide, this serum deeply hydrates, supports the skin barrier, and visibly improves radiance, pores, and fine lines for a smoother, healthier-looking complexion.

This lightweight antioxidant serum helps neutralise surface free radicals—the particles that make skin more vulnerable to damage and sensitivity—while boosting hydration and protecting the skin barrier. Day after day, skin looks healthier, more radiant, and feels stronger against external aggressors.

Key Benefits:

• Strengthens skin against daily stressors

• Neutralises surface free radicals to protect the skin barrier

• Visibly improves radiance, pores & fine lines

• Deep hydration with Triple Hyaluronic Acid

• Supports skin barrier and boosts radiance with Niacinamide

• Suitable for sensitive skin and post aesthetic procedure care (such as Intense Pulsed Light or microneedling)

Clinically proven results:

– 100% protection against oxidative stress¹, anti-pollution and blue light²

– 100% feel skin instantly moisturised³

– 100% noticed boosted radiance in 3 days³

– 28% reduction in visible pores in 4 weeks⁴

– 32% reduction in fine lines in 4 weeks⁵

– 86% reduction in signs of sensitivity⁶

AM | PM Regime:

Pair with Cetaphil Repair & Renew Serum overnight to visibly improve overall skin quality of stressed, sensitive skin in just 2 weeks.

Cetaphil has been a trusted skincare brand for over 75 years. We are the #1 dermatologist-recommended brand in the UK and the leading sensitive skin research brand worldwide. Our gentle, effective skincare products have been tested in more than 850 clinical trials involving over 32,000 participants.

¹ MDA skin lipid damage test, N=10

² Catalase level, N=10

³ Self-assessment questionnaire, N=44

⁴ Clinical grading, N=40

⁵ Self-assessment questionnaire, N=40

⁶ Sensiscale-10, N=44

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FEATURES

Stronger skin against daily stressors
Triple hyaluronic acid & niacinamide
Visibly improves radiance, pores & fine lines
Dermatologist Recommended Sensitive Skin
Designed for sensitive skin
Suitable for post-procedures
Fragrance Free
Won't Clog Pores
Clinically Tested
Hypoallergenic

FEATURES

Non-comedogenic
Fragrance free
Dermatologist tested
Defends against the 5 signs of skin sensitivity

THE ROUTINE

Step 2: REPAIR AND RENEW SERUM PM

Apply serum on cleansed face at nighttime. Use light tapping motion with your fingertips.

INGREDIENTS

Water, Dicaprylyl Carbonate, Glycerin,1,2-Hexanediol, Polyglyceryl-6 Distearate, Distarch Phosphate, 4-T-Butylcyclohexanol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Anhydroxylitol, Bisabolol, Caprylyl/Capryl Glucoside, Cetyl Alcohol, Citric Acid, Dunaliella Salina Extract (Algae), Ethylhexylglycerin, Globularia Alypum Leaf Extract(Blue Daisy), Hydrolyzed Hyaluronic Acid, Jojoba Esters, Palmitoyl Tripeptide-5, Panthenol (Vitamin B5), Pantolactone, Pentylene Glycol, Phenoxyethanol, Polyglyceryl-3 Beeswax, Polyisobutene, Potassium Sorbate, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Benzoate, Sodium Hyaluronate, Sodium Hydroxide, Sodium PCA, Sorbitan Oleate, Tocopherol (Vitamin E), Xylitol, Xylitylglucoside

FIND OUT MORE

Cetaphil Repair & Renew Serum (PM) 30ml

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Rated 5 out of 5 by kamilep4_9425 from Smooth and good absorbing I absolutely love this day serum. The glass bottle packaging feels premium and sturdy, and it gives the product a really high-quality, luxurious feel from the first use. The texture is light, smooth, and absorbs quickly into the skin, making it perfect for daytime wear and layering under moisturizer or makeup. It leaves my skin feeling gently tight and firm, but still comfortable and hydrated throughout the day. Most importantly, it hasn’t caused any breakouts at all. My skin feels balanced and calm, and over time it looks healthier and more even. Overall, this serum performs beautifully and fits effortlessly into my morning routine.

Date published: 2026-02-01

Rated 5 out of 5 by rebecas80_1911 from Amazing !! Lightweight, calming, and gives my ski I’ve been using the Cetaphil Advanced Defence Serum every morning and honestly, it’s become one of those products I actually look forward to applying. The texture is super lightweight and sinks in really quickly, so it layers perfectly under moisturiser and SPF without pilling. My skin feels hydrated and calm all day, but the biggest thing I’ve noticed is the healthy glow it gives — my skin looks fresher and more radiant even without makeup. It’s also been great for my sensitive skin, with no stinging or irritation at all. It just feels like a really easy, everyday serum that protects your skin while making it look naturally glowy.

Date published: 2026-01-14

Rated 5 out of 5 by ChanayH from I love this 🫶🥰 I have been using this for about 3 weeks and it has drastically changed my complexion I have smoothed out acne scarring and my enlarged pores have shrunk and are minimal I also have found that my natural tone is being enhanced and I look glowing it has the added advantage of including thalidomide acid as well as niacinamide and also helps with blue light and anti-pollution and has Gallic-AOX power rich in antioxidants to help with skin sensitivity and to defend against oxidative stress in have found this to work great with my skin and plumps my son ready for the day I will definitely give this thumbs up 👍 and a recommend 🫶🥰

Date published: 2026-02-23

Rated 5 out of 5 by paulinak31_2707 from Doing a job I’ve been using Cetaphil Advanced Defence Serum AM for the past 10 days and I can already see a huge difference in my skin. It feels deeply hydrated, whereas it was always dehydrated before. My pores look less visible and my complexion is much more radiant and healthy-looking. I use the AM serum every morning and pair it with the PM serum from the same line in the evening. The formula is excellent, lightweight, and absorbs well without feeling heavy. It’s especially great for tired, stressed skin and instantly makes my face look fresher and more rested. I’m really impressed with the results and will definitely continue using it.

Date published: 2026-01-15

Rated 5 out of 5 by beautycorner_nr1_9422 from I love it I love this serum, the formula feels smooth and light. It instantly absorbs into skin without causing any irritation or discomfort. Not sticky or greasy at all. Have a lovely gel texture. The scent of the product light but smells lovely. The ingredients include my favourite hyaluronic acid and niacinamide. After a few weeks of use my skin feels healthier and I noticed that my skin doesn’t appear as tired at the end of the day, my pores and my fine lines look less visible too. Overall i have noticed an improvement in the appearance of my skins health and i would recommend this to anyone whi have dry /sensitive skin or anyone who is looking to have healthier looking skin

Date published: 2026-01-16

Rated 5 out of 5 by volky_ig_9641 from Healthy & Balanced skin all day I absolutely love the Cetaphil Advanced Defence AM Serum. The pipette makes it so easy to dispense the perfect amount, and a little truly goes a long way, so the bottle will last for ages. The packaging is really nice and feels high-quality. The serum itself is lightweight, absorbs quickly, and layers beautifully under moisturizer and makeup without feeling greasy. It leaves my skin feeling fresh, hydrated, and comfortable all day long. My skin looks healthier and more balanced, and it’s gentle enough for sensitive skin while still being effective. This has become a staple in my morning routine.

Date published: 2026-01-16

Rated 4 out of 5 by GurkaranS from All day stress free skin Cetaphil advanced defence serum (AM) has triple hyaluronic acid which leaves skin hydrating all day and stress free. Must try with its (PM) serum. Never forget sunscreen.

Date published: 2026-02-28

Rated 5 out of 5 by mixa11_3047 from Amazing This serum is absolutely amazing. I love the way it feels on my skin. It’s a lightweight gel texture that just absorbs into the skin. My skin is always freaking out daily due to a damaged skin barrier. However within 2 weeks this has calmed my barrier down completely and made my skin soft and glowy again. It has a dropper applicator which I love as I can get just the right amount out. My skin drinksss this up and I’ve gotten so many compliments after using this serum consistently. I also find that it works really well with the night serum and you see faster results with the two together.

Date published: 2026-01-14

Cetaphil Advanced Defence Serum (AM) Reviews - page 2

Cetaphil Advanced Defence Serum (AM) 30ml

Cetaphil Advanced Defence Serum (AM) 30ml

FEATURES

FEATURES

THE ROUTINE

Cetaphil Repair & Renew Serum (PM) 30ml

INGREDIENTS

FIND OUT MORE

Cetaphil Repair & Renew Serum (PM) 30ml

Reviews

Questions