Cetaphil Advanced Defence Serum (AM) 30ml

Name: Cetaphil Advanced Defence Serum (AM) 30ml
Brand: Cetaphil
SKU: 3499320018067
Availability: InStock

Cetaphil Advanced Defence Serum (AM) 30ml

Protect your skin every morning with Cetaphil Advanced Defence (AM) Serum, clinically proven to strengthen sensitive skin against daily stressors.

Formulated with Gallic-AOX Power™, a potent antioxidant complex featuring Gallic Acid and Vitamin E, proven to be two times more effective than Vitamin C for sensitive skin. Combined with Triple Hyaluronic Acid and Niacinamide, this serum deeply hydrates, supports the skin barrier, and visibly improves radiance, pores, and fine lines for a smoother, healthier-looking complexion.

This lightweight antioxidant serum helps neutralise surface free radicals—the particles that make skin more vulnerable to damage and sensitivity—while boosting hydration and protecting the skin barrier. Day after day, skin looks healthier, more radiant, and feels stronger against external aggressors.

Key Benefits:

• Strengthens skin against daily stressors

• Neutralises surface free radicals to protect the skin barrier

• Visibly improves radiance, pores & fine lines

• Deep hydration with Triple Hyaluronic Acid

• Supports skin barrier and boosts radiance with Niacinamide

• Suitable for sensitive skin and post aesthetic procedure care (such as Intense Pulsed Light or microneedling)

Clinically proven results:

– 100% protection against oxidative stress¹, anti-pollution and blue light²

– 100% feel skin instantly moisturised³

– 100% noticed boosted radiance in 3 days³

– 28% reduction in visible pores in 4 weeks⁴

– 32% reduction in fine lines in 4 weeks⁵

– 86% reduction in signs of sensitivity⁶

AM | PM Regime:

Pair with Cetaphil Repair & Renew Serum overnight to visibly improve overall skin quality of stressed, sensitive skin in just 2 weeks.

Cetaphil has been a trusted skincare brand for over 75 years. We are the #1 dermatologist-recommended brand in the UK and the leading sensitive skin research brand worldwide. Our gentle, effective skincare products have been tested in more than 850 clinical trials involving over 32,000 participants.

¹ MDA skin lipid damage test, N=10

² Catalase level, N=10

³ Self-assessment questionnaire, N=44

⁴ Clinical grading, N=40

⁵ Self-assessment questionnaire, N=40

⁶ Sensiscale-10, N=44

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FEATURES

Stronger skin against daily stressors
Triple hyaluronic acid & niacinamide
Visibly improves radiance, pores & fine lines
Dermatologist Recommended Sensitive Skin
Designed for sensitive skin
Suitable for post-procedures
Fragrance Free
Won't Clog Pores
Clinically Tested
Hypoallergenic

FEATURES

Non-comedogenic
Fragrance free
Dermatologist tested
Defends against the 5 signs of skin sensitivity

THE ROUTINE

Step 2: REPAIR AND RENEW SERUM PM

Apply serum on cleansed face at nighttime. Use light tapping motion with your fingertips.

INGREDIENTS

Water, Dicaprylyl Carbonate, Glycerin,1,2-Hexanediol, Polyglyceryl-6 Distearate, Distarch Phosphate, 4-T-Butylcyclohexanol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Anhydroxylitol, Bisabolol, Caprylyl/Capryl Glucoside, Cetyl Alcohol, Citric Acid, Dunaliella Salina Extract (Algae), Ethylhexylglycerin, Globularia Alypum Leaf Extract(Blue Daisy), Hydrolyzed Hyaluronic Acid, Jojoba Esters, Palmitoyl Tripeptide-5, Panthenol (Vitamin B5), Pantolactone, Pentylene Glycol, Phenoxyethanol, Polyglyceryl-3 Beeswax, Polyisobutene, Potassium Sorbate, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Benzoate, Sodium Hyaluronate, Sodium Hydroxide, Sodium PCA, Sorbitan Oleate, Tocopherol (Vitamin E), Xylitol, Xylitylglucoside

FIND OUT MORE

Cetaphil Repair & Renew Serum (PM) 30ml

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Rated 5 out of 5 by rebecas80_1911 from Amazing !! Lightweight, calming, and gives my ski I’ve been using the Cetaphil Advanced Defence Serum every morning and honestly, it’s become one of those products I actually look forward to applying. The texture is super lightweight and sinks in really quickly, so it layers perfectly under moisturiser and SPF without pilling. My skin feels hydrated and calm all day, but the biggest thing I’ve noticed is the healthy glow it gives — my skin looks fresher and more radiant even without makeup. It’s also been great for my sensitive skin, with no stinging or irritation at all. It just feels like a really easy, everyday serum that protects your skin while making it look naturally glowy.

Date published: 2026-01-14

Rated 5 out of 5 by mixa11_3047 from Amazing This serum is absolutely amazing. I love the way it feels on my skin. It’s a lightweight gel texture that just absorbs into the skin. My skin is always freaking out daily due to a damaged skin barrier. However within 2 weeks this has calmed my barrier down completely and made my skin soft and glowy again. It has a dropper applicator which I love as I can get just the right amount out. My skin drinksss this up and I’ve gotten so many compliments after using this serum consistently. I also find that it works really well with the night serum and you see faster results with the two together.

Date published: 2026-01-14

Rated 5 out of 5 by victoriat202_9395 from Perfect office essential I love this serum, the formula feels skin smooth and light while also moisturised. The scent is really light and I really like the defence against blue light which I think is essential when you work in an office or infront of a screen most of the day. After two weeks of use my skin feels healthier and I noticed that my skin doesn’t appear as tired at the end of the day, my pores look less visible too. Overall after using for two weeks o have noticed an improvement in the appearance of my skins health and o would recommend this to anyone who is looking to have healthier looking skin and again the protection against blue light too! I like the added touch that this serum can also protect your skin against pollution, this is a major benefit when you are in more urban areas.

Date published: 2026-01-14

Rated 5 out of 5 by anamf8_7586 from Daily hydration I’ve been using the Cetaphil Advanced Defence Serum AM every morning for several weeks, and it’s quickly become a key step in my skincare routine. The serum comes in a sleek bottle with a pump, which makes it easy to dispense just the right amount. The texture is light and silky — it glides on smoothly and absorbs almost instantly without leaving any stickiness. This serum is great for daily hydration. It gives my skin a fresh, moisturised feel that lasts through the day — even in dryer or colder weather. I love that it layers well under SPF and makeup without pilling or feeling heavy.

Date published: 2026-01-14

Rated 5 out of 5 by sarahl354_8435 from Fresh daily serum Definitely a great product. I'm usually quite cautious because of sensitive skin. This doesn't have a scent or strong one. You only need a small amount, it absorbs well, makes my skin feel fresh and soft. I've noticed my skin has been a lot smoother with less breakouts. My skin Definitely feels revitalised in the mornings, i dont need to use as much makeup afterwards! Using this along side the PM one is definitely recommended

Date published: 2026-01-14

Rated 5 out of 5 by poojap62_7049 from Effects really good This Advanced serum am really worth it i using this serum for a few weeks, and it’s been brilliant. It absorbs quickly, feels lightweight, and has noticeably improved my skin texture and glow without causing any irritation. it perfect for sensitive skin. My fine lines are softer, and my skin feels smoother and more even. A great product that really delivers results. Highly recommended. no sticky feeling.

Date published: 2026-01-14

Rated 5 out of 5 by martam111_5774 from Love it I have been really enjoying the Cetaphil Advanced Defence Serum AM as a daily step in my morning routine. It feels lightweight and comfortable on the skin while offering solid antioxidant protection against daily external stressors. The Gallic AOX Power complex with Gallic Acid and Vitamin E helps keep my skin calmer and less reactive throughout the day. Thanks to the triple hyaluronic acid, my skin stays well hydrated, smooth and fresh looking without any heaviness. Niacinamide is a great addition too. Over time my pores look more refined and my skin has a healthier, more radiant appearance. It absorbs quickly, layers well under other products and causes no irritation or breakouts. Paired with the Cetaphil Repair & Renew Serum at night, it noticeably improves overall skin quality within a couple of weeks. A great everyday serum for sensitive, stressed skin that needs protection and hydration.

Date published: 2026-01-14

Rated 5 out of 5 by chloejadebeauty_8217 from Amazing morning serum I love this serum. It soothes my irritated and dry skin and gives me the hydration and moisture that I need. I have been trying this product for a few weeks and it’s definitely improved skin radiance, pore visibility and reduced my skin sensitivity. It has amazing ingredients such as Hyaluronic Acid, Niacinamide and Gallic-AOX Power. I will definitely be buying another one when it runs out

Date published: 2026-01-14

Cetaphil Advanced Defence Serum (AM) Reviews - page 2

Cetaphil Advanced Defence Serum (AM) 30ml

Cetaphil Advanced Defence Serum (AM) 30ml

FEATURES

FEATURES

THE ROUTINE

Cetaphil Repair & Renew Serum (PM) 30ml

INGREDIENTS

FIND OUT MORE

Cetaphil Repair & Renew Serum (PM) 30ml

Reviews

Questions