Cetaphil Advanced Defence Serum (AM) 30ml

Cetaphil Advanced Defence Serum (AM) 30ml

Protect your skin every morning with Cetaphil Advanced Defence (AM) Serum, clinically proven to strengthen sensitive skin against daily stressors.

Formulated with Gallic-AOX Power™, a potent antioxidant complex featuring Gallic Acid and Vitamin E, proven to be two times more effective than Vitamin C for sensitive skin. Combined with Triple Hyaluronic Acid and Niacinamide, this serum deeply hydrates, supports the skin barrier, and visibly improves radiance, pores, and fine lines for a smoother, healthier-looking complexion.

This lightweight antioxidant serum helps neutralise surface free radicals—the particles that make skin more vulnerable to damage and sensitivity—while boosting hydration and protecting the skin barrier. Day after day, skin looks healthier, more radiant, and feels stronger against external aggressors.

Key Benefits:

• Strengthens skin against daily stressors

• Neutralises surface free radicals to protect the skin barrier

• Visibly improves radiance, pores & fine lines

• Deep hydration with Triple Hyaluronic Acid

• Supports skin barrier and boosts radiance with Niacinamide

• Suitable for sensitive skin and post aesthetic procedure care (such as Intense Pulsed Light or microneedling)

Clinically proven results:

– 100% protection against oxidative stress¹, anti-pollution and blue light²

– 100% feel skin instantly moisturised³

– 100% noticed boosted radiance in 3 days³

– 28% reduction in visible pores in 4 weeks⁴

– 32% reduction in fine lines in 4 weeks⁵

– 86% reduction in signs of sensitivity⁶

AM | PM Regime:

Pair with Cetaphil Repair & Renew Serum overnight to visibly improve overall skin quality of stressed, sensitive skin in just 2 weeks.

Cetaphil has been a trusted skincare brand for over 75 years. We are the #1 dermatologist-recommended brand in the UK and the leading sensitive skin research brand worldwide. Our gentle, effective skincare products have been tested in more than 850 clinical trials involving over 32,000 participants.

¹ MDA skin lipid damage test, N=10

² Catalase level, N=10

³ Self-assessment questionnaire, N=44

⁴ Clinical grading, N=40

⁵ Self-assessment questionnaire, N=40

⁶ Sensiscale-10, N=44

FEATURES

  • Stronger skin against daily stressors
  • Triple hyaluronic acid & niacinamide
  • Visibly improves radiance, pores & fine lines
  • Dermatologist Recommended Sensitive Skin
  • Designed for sensitive skin
  • Suitable for post-procedures
  • Fragrance Free
  • Won't Clog Pores
  • Clinically Tested
  • Hypoallergenic

FEATURES

  • Non-comedogenic

  • Fragrance free

  • Dermatologist tested

  • Defends against the 5 signs of skin sensitivity

INGREDIENTS

 

Water, Dicaprylyl Carbonate, Glycerin,1,2-Hexanediol, Polyglyceryl-6 Distearate, Distarch Phosphate, 4-T-Butylcyclohexanol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Anhydroxylitol, Bisabolol, Caprylyl/Capryl Glucoside, Cetyl Alcohol, Citric Acid, Dunaliella Salina Extract (Algae), Ethylhexylglycerin, Globularia Alypum Leaf Extract(Blue Daisy), Hydrolyzed Hyaluronic Acid, Jojoba Esters, Palmitoyl Tripeptide-5, Panthenol (Vitamin B5), Pantolactone, Pentylene Glycol, Phenoxyethanol, Polyglyceryl-3 Beeswax, Polyisobutene, Potassium Sorbate, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Benzoate, Sodium Hyaluronate, Sodium Hydroxide, Sodium PCA, Sorbitan Oleate, Tocopherol (Vitamin E), Xylitol, Xylitylglucoside

 

Cetaphil Advanced Defence Serum (AM) 30ml 
                    Ingredients

Reviews

Rated 5 out of 5 by from Fresh and awakening smell Smells so fresh and awakening which felt perfect for a morning serum. It’s light weight and runny so you only need a small amount meaning it lasts a while. I haven’t seen much difference yet but excited to carry on using it
Date published: 2026-02-08
Rated 5 out of 5 by from Very good Very good serum. It reduces the redness. Looks very good to wear. It improved the radiance and the pores. Looks very good for fine lines. U am very happy with it and I highly recommend it. It doesent breakout.
Date published: 2026-02-08
Rated 5 out of 5 by from Smooth and good absorbing I absolutely love this day serum. The glass bottle packaging feels premium and sturdy, and it gives the product a really high-quality, luxurious feel from the first use. The texture is light, smooth, and absorbs quickly into the skin, making it perfect for daytime wear and layering under moisturizer or makeup. It leaves my skin feeling gently tight and firm, but still comfortable and hydrated throughout the day. Most importantly, it hasn’t caused any breakouts at all. My skin feels balanced and calm, and over time it looks healthier and more even. Overall, this serum performs beautifully and fits effortlessly into my morning routine.
Date published: 2026-02-01
Rated 5 out of 5 by from Amazing !! Lightweight, calming, and gives my ski I’ve been using the Cetaphil Advanced Defence Serum every morning and honestly, it’s become one of those products I actually look forward to applying. The texture is super lightweight and sinks in really quickly, so it layers perfectly under moisturiser and SPF without pilling. My skin feels hydrated and calm all day, but the biggest thing I’ve noticed is the healthy glow it gives — my skin looks fresher and more radiant even without makeup. It’s also been great for my sensitive skin, with no stinging or irritation at all. It just feels like a really easy, everyday serum that protects your skin while making it look naturally glowy.
Date published: 2026-01-14
Rated 5 out of 5 by from Leaves skin smooth, hydrated and calm! I’ve genuinely loved using the Cetaphil Advanced Defense Serum in the mornings! It absorbs instantly without feeling sticky, leaving my skin feeling smooth, hydrated and calm throughout the day which is a big win for me as I have sensitive skin. It’s lightweight yet deeply nourishing - perfect under makeup or SPF. My complextion looks slightly brighter and more even, and it feels protected against dryness and environmental stressors. A morning skincare staple I genuinely look forward to!
Date published: 2026-02-08
Rated 5 out of 5 by from Doing a job I’ve been using Cetaphil Advanced Defence Serum AM for the past 10 days and I can already see a huge difference in my skin. It feels deeply hydrated, whereas it was always dehydrated before. My pores look less visible and my complexion is much more radiant and healthy-looking. I use the AM serum every morning and pair it with the PM serum from the same line in the evening. The formula is excellent, lightweight, and absorbs well without feeling heavy. It’s especially great for tired, stressed skin and instantly makes my face look fresher and more rested. I’m really impressed with the results and will definitely continue using it.
Date published: 2026-01-15
Rated 5 out of 5 by from I love it I love this serum, the formula feels smooth and light. It instantly absorbs into skin without causing any irritation or discomfort. Not sticky or greasy at all. Have a lovely gel texture. The scent of the product light but smells lovely. The ingredients include my favourite hyaluronic acid and niacinamide. After a few weeks of use my skin feels healthier and I noticed that my skin doesn’t appear as tired at the end of the day, my pores and my fine lines look less visible too. Overall i have noticed an improvement in the appearance of my skins health and i would recommend this to anyone whi have dry /sensitive skin or anyone who is looking to have healthier looking skin
Date published: 2026-01-16
Rated 5 out of 5 by from Great serum! At first when you use the serum you breakout slightly but after a few days it settles. It does dry your skin a little so a moisturiser for a top up during the day would be great. No sticky residue only feels sticky when tapping it on your skin when applying.
Date published: 2026-02-08
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