Cetaphil Advanced Defence Serum (AM) 30ml

Name: Cetaphil Advanced Defence Serum (AM) 30ml
Brand: Cetaphil
SKU: 3499320018067
Availability: InStock

Cetaphil Advanced Defence Serum (AM) 30ml

Protect your skin every morning with Cetaphil Advanced Defence (AM) Serum, clinically proven to strengthen sensitive skin against daily stressors.

Formulated with Gallic-AOX Power™, a potent antioxidant complex featuring Gallic Acid and Vitamin E, proven to be two times more effective than Vitamin C for sensitive skin. Combined with Triple Hyaluronic Acid and Niacinamide, this serum deeply hydrates, supports the skin barrier, and visibly improves radiance, pores, and fine lines for a smoother, healthier-looking complexion.

This lightweight antioxidant serum helps neutralise surface free radicals—the particles that make skin more vulnerable to damage and sensitivity—while boosting hydration and protecting the skin barrier. Day after day, skin looks healthier, more radiant, and feels stronger against external aggressors.

Key Benefits:

• Strengthens skin against daily stressors

• Neutralises surface free radicals to protect the skin barrier

• Visibly improves radiance, pores & fine lines

• Deep hydration with Triple Hyaluronic Acid

• Supports skin barrier and boosts radiance with Niacinamide

• Suitable for sensitive skin and post aesthetic procedure care (such as Intense Pulsed Light or microneedling)

Clinically proven results:

– 100% protection against oxidative stress¹, anti-pollution and blue light²

– 100% feel skin instantly moisturised³

– 100% noticed boosted radiance in 3 days³

– 28% reduction in visible pores in 4 weeks⁴

– 32% reduction in fine lines in 4 weeks⁵

– 86% reduction in signs of sensitivity⁶

AM | PM Regime:

Pair with Cetaphil Repair & Renew Serum overnight to visibly improve overall skin quality of stressed, sensitive skin in just 2 weeks.

Cetaphil has been a trusted skincare brand for over 75 years. We are the #1 dermatologist-recommended brand in the UK and the leading sensitive skin research brand worldwide. Our gentle, effective skincare products have been tested in more than 850 clinical trials involving over 32,000 participants.

¹ MDA skin lipid damage test, N=10

² Catalase level, N=10

³ Self-assessment questionnaire, N=44

⁴ Clinical grading, N=40

⁵ Self-assessment questionnaire, N=40

⁶ Sensiscale-10, N=44

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FEATURES

Stronger skin against daily stressors
Triple hyaluronic acid & niacinamide
Visibly improves radiance, pores & fine lines
Dermatologist Recommended Sensitive Skin
Designed for sensitive skin
Suitable for post-procedures
Fragrance Free
Won't Clog Pores
Clinically Tested
Hypoallergenic

FEATURES

Non-comedogenic
Fragrance free
Dermatologist tested
Defends against the 5 signs of skin sensitivity

THE ROUTINE

Step 2: REPAIR AND RENEW SERUM PM

Apply serum on cleansed face at nighttime. Use light tapping motion with your fingertips.

INGREDIENTS

Water, Dicaprylyl Carbonate, Glycerin,1,2-Hexanediol, Polyglyceryl-6 Distearate, Distarch Phosphate, 4-T-Butylcyclohexanol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Anhydroxylitol, Bisabolol, Caprylyl/Capryl Glucoside, Cetyl Alcohol, Citric Acid, Dunaliella Salina Extract (Algae), Ethylhexylglycerin, Globularia Alypum Leaf Extract(Blue Daisy), Hydrolyzed Hyaluronic Acid, Jojoba Esters, Palmitoyl Tripeptide-5, Panthenol (Vitamin B5), Pantolactone, Pentylene Glycol, Phenoxyethanol, Polyglyceryl-3 Beeswax, Polyisobutene, Potassium Sorbate, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Benzoate, Sodium Hyaluronate, Sodium Hydroxide, Sodium PCA, Sorbitan Oleate, Tocopherol (Vitamin E), Xylitol, Xylitylglucoside

FIND OUT MORE

Cetaphil Repair & Renew Serum (PM) 30ml

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Rated 5 out of 5 by rebecas80_1911 from Amazing !! Lightweight, calming, and gives my ski I’ve been using the Cetaphil Advanced Defence Serum every morning and honestly, it’s become one of those products I actually look forward to applying. The texture is super lightweight and sinks in really quickly, so it layers perfectly under moisturiser and SPF without pilling. My skin feels hydrated and calm all day, but the biggest thing I’ve noticed is the healthy glow it gives — my skin looks fresher and more radiant even without makeup. It’s also been great for my sensitive skin, with no stinging or irritation at all. It just feels like a really easy, everyday serum that protects your skin while making it look naturally glowy.

Date published: 2026-01-14

Rated 5 out of 5 by paulinak31_2707 from Doing a job I’ve been using Cetaphil Advanced Defence Serum AM for the past 10 days and I can already see a huge difference in my skin. It feels deeply hydrated, whereas it was always dehydrated before. My pores look less visible and my complexion is much more radiant and healthy-looking. I use the AM serum every morning and pair it with the PM serum from the same line in the evening. The formula is excellent, lightweight, and absorbs well without feeling heavy. It’s especially great for tired, stressed skin and instantly makes my face look fresher and more rested. I’m really impressed with the results and will definitely continue using it.

Date published: 2026-01-15

Rated 5 out of 5 by beautycorner_nr1_9422 from I love it I love this serum, the formula feels smooth and light. It instantly absorbs into skin without causing any irritation or discomfort. Not sticky or greasy at all. Have a lovely gel texture. The scent of the product light but smells lovely. The ingredients include my favourite hyaluronic acid and niacinamide. After a few weeks of use my skin feels healthier and I noticed that my skin doesn’t appear as tired at the end of the day, my pores and my fine lines look less visible too. Overall i have noticed an improvement in the appearance of my skins health and i would recommend this to anyone whi have dry /sensitive skin or anyone who is looking to have healthier looking skin

Date published: 2026-01-16

Rated 4 out of 5 by barbarastracciatella from Trusted skincare product I’ve been using this Advanced Defence/AM serum from Cetaphil in the mornings and overall it’s been very nice to use. The texture feels smooth and lightweight on the skin and it absorbs quickly, which is great for daytime before moisturizer and SPF. It doesn’t irritate my sensitive skin and feels gentle, which I really like. A lot of reviewers online mention how these Cetaphil serums help with hydration and strengthening the skin barrier, especially for sensitive skin types, and I can see that here too it keeps my skin feeling comfortable throughout the day without heaviness

Date published: 2026-01-17

Rated 5 out of 5 by loisteleri_8245 from Great day serum! The perfect day serum, great consistency allowing it to sink into the skin without feeling too heavy. It also didn’t feel greasy or oily and left my skin feeling hydrated allowing it to sit nicely under my make up. It didn’t cause my foundation to pill and in all honestly made my make up look really good and luminous. Didn’t break me out and definitely helped calm my skin down. Great ingredients and would recommend for all skin types.

Date published: 2026-01-18

Rated 5 out of 5 by volky_ig_9641 from Healthy & Balanced skin all day I absolutely love the Cetaphil Advanced Defence AM Serum. The pipette makes it so easy to dispense the perfect amount, and a little truly goes a long way, so the bottle will last for ages. The packaging is really nice and feels high-quality. The serum itself is lightweight, absorbs quickly, and layers beautifully under moisturizer and makeup without feeling greasy. It leaves my skin feeling fresh, hydrated, and comfortable all day long. My skin looks healthier and more balanced, and it’s gentle enough for sensitive skin while still being effective. This has become a staple in my morning routine.

Date published: 2026-01-16

Rated 5 out of 5 by aprilb109_1900 from Brilliant!! I’ve been using the Cetaphil Advanced Defence Serum (AM) each morning and it fits perfectly into my routine. The absorption is fast and the appearance of my skin looks smoother and more even. The afterfeel is comfortable and non-greasy, making it easy to layer under moisturiser or SPF. There’s little to no scent, which I appreciate, and the durability is great as a small amount lasts a long time.

Date published: 2026-01-18

Rated 5 out of 5 by Anonymous from Leaves my skin hydrated and plumper I’ve added this serum into my skin care routine for the past two weeks and paired it with the PM repair and renew serum. This has been the ideal addition to my routine during these cold winter months as there are additional stressors for my skin at this time of the year. My skin is definitely feeling more hydrated, plumper and healthier. It absorbs well into my skin and is a nice consistency. I am looking forward to continuing to use this and seeing more benefits as time goes on. It’s great that it’s fragrance free and doesn’t irritate my skin too.

Date published: 2026-01-17

Cetaphil Advanced Defence Serum (AM) Reviews - page 2

Cetaphil Advanced Defence Serum (AM) 30ml

Cetaphil Advanced Defence Serum (AM) 30ml

FEATURES

FEATURES

THE ROUTINE

Cetaphil Repair & Renew Serum (PM) 30ml

INGREDIENTS

FIND OUT MORE

Cetaphil Repair & Renew Serum (PM) 30ml

Reviews

Questions